Association of cerebrospinal fluid anti-ribosomal P protein antibodies with diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosus
We explored the relationship of antibodies to the whole ribosomal P proteins (P0, P1, P2) in cerebrospinal fluid (CSF) with diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosus (SLE). CSF were obtained from 71 SLE patients (52 patients with diffuse psychiatric/neuropsychological syndromes [diffuse NP-SLE] and 19 patients with neurologic syndromes or peripheral neuropathy [focal NP-SLE]) as well as from 24 patients with non-inflammatory neurological disease. IgG antibodies to the C-terminal 22 amino acids ribosomal P synthetic peptide (anti-PC22) and those to purified bovine ribosomal P proteins (P0, P1, P2) (anti-whole P) were determined by enzyme-linked immunosorbent assay, using affinity purified IgG anti-PC22 as standard. The concentrations of antibodies to epitopes other than the C-terminal 22 amino acids of ribosomal P proteins were calculated by subtracting anti-PC22 from anti-whole P (anti-PEX.C22). CSF anti-whole P were significantly elevated in diffuse NP-SLE compared with focal NP-SLE or control patients. By contrast, there were no significant differences in CSF anti-PC22 levels among the 3 groups. Of note, CSF anti-PEX.C22 were significantly elevated in diffuse NP-SLE compared with the other 2 groups. CSF anti-PEX.C22 were not significantly correlated with CSF anti-PC22, but with CSF antibodies against the recombinant ribosomal P0 protein lacking the C-terminal 22 amino acids (C22-depleted rP0). Moreover, CSF anti-PEX.C22 or CSF anti- C22-depleted rP0, but not CSF anti-PC22, were significantly correlated with CSF anti-neuronal cell antibodies (anti-N). These results indicate that CSF IgG antibodies to the epitopes other than the C-terminal 22 amino acids of ribosomal P proteins, which might contain one of the major targets of CSF anti-N, are associated with the development of diffuse NP-SLE.
Los Angeles County Hospital
Monthly Paper Selection
Journal RSS (FEEDS):
By following the link below, you will be redirected to my Bloglines website. I set up a page with FEEDS from the main Rheumatology Journals, Internal Medicine Journals and Immunology Basic Science Journals:
http://www.bloglines.com/public/brunostoliver
In addition, I made available some FEEDS from Rheumatology Journals below, but be aware that this is not a complete list of each Journal issue. To get the complete list, click in the link above and you will be redirected to bloglines.com
Medscape Rheumatology Headlines
Physician's First Watch: Current Issue
Arthritis & Rheumatism
Annals of the Rheumatic Diseases current issue
Rheumatology - current issue
Current Opinion in Rheumatology - Current Table Of Contents
CER - Recent Issue
Arthritis Research & Therapy - Latest articles
JCR: Journal of Clinical Rheumatology - Current Table Of Contents
Nature Clinical Practice Rheumatology
Lupus current issue
Journal Links (Blogroll from Bloglines)
Rheumatology Journals Schedule
- Arthritis and Rheumatism: Monthly
- Annals of Rheumatic Disease (The EULAR Journal): Monthly
- Journal of Rheumatology: bi-weekly (only e-mail TOC/no RSS)
- Rheumatology (Oxford): Monthly
- Current Opinion in Rheumatology (COR): 6 issues/year (bi-monthly)
- Clinical and Experimental Rheumatology (CER): 6 issues/year (bi-monthly)
- Arthritis Research and Therapy: 6 issues/year (bi-monthly)
- Journal of Clinical Rheumatology: 6 issues/year (bi-monthly)
- Scandinavian Journal of Rheumatology: 6 issues/year (bi-monthly) !No issues since July 2006
- Rheumatic Disease Clinics of North America: (4-5 reviews/year): Receive e-mail TOC. No RSS.
- Seminars in Arthritis and Rheumatism: 6 issues/year (bi-monthly)+ 2 Supplements: Receive e-mail TOC. No RSS.
- Nature Clinical Practice Rheumatology: Monthly
- Lupus Journal: Monthly
Internal Medicine Journals Schedule
- Archives of Internal Medicine: Bi-weelky (Monday)
- Annals of Internal Medicine: No RSS available: Bi-weekly (Tuesday) (only e-mail TOC)
- JAMA: Weekly (Wednesday)
- NEJM: Weekly (Thursday)
- Lancet: Weekly (Friday)
- British Medical Journal: Weekly (Saturday)
Monday, May 14, 2007
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment